Frequently Asked Questions 

  • SkinPen results have been graded based on G.Lemperle Wrinkle Assessment Scale, the Clinician’s Global Aesthetic Improvement Scale (CGAIS), and the Subject Global Aesthetic Improvement Scale (GAIS). The research is clear.

  • SkinPen creates hundreds to thousands of “micro” skin punctures per second to stimulate the skin’s natural wound healing process - inflammation, proliferation, and remodeling - to prompt tissue remodeling without causing scar tissue formation. Most patients can return to normal activities within 24 hours.

  • SkinPen is clinically proven to fight the appearance of neck wrinkles and reduce the appearance of acne scars. In fact, 90% of subjects in the clinical trial would recommend the treatment to friends and family. It’s a minimally invasive procedure performed in-office with little to no downtime. As the first FDA cleared microneedling device, SkinPen sets the industry standard for safety.

  • Unlike some alternatives, SkinPen has been clinically proven to be effective for women and men with all Fitzpatrick Skin Types I - VI. Likewise, unlike lasers or chemical peels that can damage skin over the long term, SkinPen treatments, when properly spaced and overseen by a physician, can be used for years

  • Yes, by design. SkinPen’s patented - and single- use - sterile needle cartridge is built with safety in mind. SkinPen is also surrounded by a custom-designed BioSheath that acts as a barrier to prevent cross contamination between procedures. That’s part of the reason SkinPen by Crown Aesthetics is the world’s first FDA-cleared microneedling device. Learn more by reviewing our patient labeling document.

  • SkinPen should not be used on patients who have active skin cancer in the treatment area(s): open wounds, sores, or irritated skin in the treatment area(s); an allergy to stainless steel or anesthetics: a hemorrhagic (bleeding) disorder or hemostatic (bleeding) dysfunction; are pregnant or nursing; or are currently taking drugs with the ingredient isotretinoin (such as Accutane). Talk to your doctor to see if this treatment is right for you.

  • Microneedling procedures tend to cost less than the alternatives, due to their non-invasive nature. The cost of SkinPen procedures varies depending on the size and the number of treatment areas. During your consultation, your physician can develop a plan to work within your budget.

  • Quite a bit. The U.S. Food and Drug Administration’s clearance covers not only the SkinPen device but the entire protocol. That includes the Skinfuse Lift HG hydrogel used to protect against abrasion and friction during the treatment, as well as the custom-designed BioSheath to prevent cross contamination.

  • BIOJUVE is powered by Xycrobe Technology that delivers potent Bioessentials around the clock to optimize skin health for a wide range of anti-aging skin concerns. These Bioessentials such as proteins, fatty acids, polypeptides and antioxidants help to support a healthy skin environment, fight oxidative stressors, promote proper skin hydration, calm the skin, decrease the appearance of erythema, help to balance sebum production.

  • Optimizing your skin's living microbiome is the most effective way to enhance skin health and vitality. Unlike traditional skincare, the Xycrobes within BIOJUVE live and thrive both on the skin’s surface and deep within the hair follicles, promoting skin health and vitality 24/7.

  • All endpoints measured in the BIOJUVE clinical study showed visible results in as little as one week with significant continuous improvement over 8 weeks.*

    *Results may vary.

  • BIOJUVE is clinically proven to create significant improvements in the appearance of texture, tone, fine lines, wrinkles, and photodamage.

  • No, there were no adverse reactions reported in the BIOJUVE clinical study.

  • One of the values of Xycrobes is that they live and thrive deep within the hair follicles. Though some Xycrobes that have not yet engrafted, or adhered, to the skin may wash away, others that have engrafted and live deep within the hair follicles will remain intact. In all cases, Xycrobes will replenish each night that the Living Biome Essentials Serum is placed on the skin.

  • Initial results can be seen in as little as 1 week, full range of results – 6 weeks. Why are a few days enough to see the first results with DefenAge?

    It is enough because our unique cosmetic ingredient, the defensin-molecules, works together with the same “fresh” skin master cells that our body uses to heal wounds. Our skin heals scratches within a few days, meaning that it is enough for the body to produce a visible effect that fast. TIP: Exfoliate skin to see results faster. Remove old cells from the skin's surface to make new skin visible using an exfoliating mask. It also helps keep pores clean. DefenAge's exfoliation solution is the 2-Minute Reveal Masque, part of all our kits. It will take only 2 minutes, once or twice a week.

  • Yes, you can! This is a unique property of defensin-molecules, our core anti-aging technology. Due to an entirely different mechanism of action, DefenAge can be combined with almost any other skincare products and ingredients, including Retin-A and retinols, vitamin C, hyaluronic acid, and growth factors. The rule is simple: layer all other products in your skincare routine before layering DefenAge's Step 2 and 3.

  • The rule is simple: Apply Step 2 and Step 3 at the very end! DefenAge's Step 2 and 3 should be the last steps in your skincare routine; only sunscreen and makeup should be layered on top of our bioserum in the morning and nothing at night. This is the order for using the products that we recommend: STEP 1 - Cleansing: Facial cleanser, morning and evening. Please use any cleanser you like or DefenAge's 1-Step Multi-Cleanse. Exfoliate the skin after cleansinig with 2-Minute Reveal Masque once or twice a week. "ANYTHING ELSE" STEP: Any other skincare products that you would like to use, including vitamin C, Retin A/retinols etc. STEP 2 - Hydration: FACE: 24/7 Barrier Balance Cream on the face, except the skin around eyes; morning and evening. EYES: 3D Eye Radiance Cream for the skin around eyes; morning and evening. NECK: 6-Week Perfection Neck Tightening Cream for the skin on the neck; morning and evening. STEP 3 - New Skin: 8-in-1 BioSerum Anti-Aging Cream on the entire face including the skin around eyes and on the neck; morning and evening. SUNSCREN and MAKEUP in the morning.

  • Please use the exact quantity of the defensin products as we recommend: one pump per area (one pump rule). Do not overdose, more is not better. Our formulas are very well balanced and refined on concentrations of defensins and other ingredients to deliver results. USE: 24/7 Barrier Balance Cream: ONE (up to two) pumps on the face. 3D Eye Radiance Cream: ONE pump for both eyes. 6-Week Perfection Neck Tightening Cream: ONE pump on the neck and décolleté. 8-in-1 BioSerum: ONE pump on the face and ONE pump on the neck and décolleté.

  • In addition to stimulating new skin, defensins have an extra beneficial action to "close gaps" between cells on the surface of our skin. It means that defensins prevent water loss from the skin. The 8-in-1 BioSerum contains the highest concentration of defensins, meaning that once the serum is applied, penetration into the skin surface other products will be compromised (if "nothing/water goes out" - then "nothing is goes in"). This is a unique property of defensin molecules, therefore we always advise layering the 8-in-1 BioSerum as the last step of the skincare regimen, only sunscreen and makeup (if any) is recommended to be applied on top of the 8-in-1 BioSerum in the morning and nothing layered on top at night.

  • We built our formulas with clean beauty in mind, our formulas are clean and do not contain most common harmful or questionable ingredients. In addition, please know that our formulas do not contain retinols. Unfortunately, we do not have formal clinical studies relating to safety during pregnancy and breastfeeding, therefore, before you start using DefenAge, we advise to consult the ingredient list with your OBGYN to be double sure. The detailed ingredient lists are shown on the product pages of our website.

  • Yes it is. The 8-in-1 BioSerum is safe for acne prone skin, our bio serum underwent multiple safety studies that returned an outstanding safety profile. Please be sure that you use the exact quantity of the product that we recommended, and do not exceed it: 1 pump of the bio serum for entire face and 1 pump on the neck.

  • On the top of the bottles, there are directions in black lettering. Remove the white plug from the nozzle, hold the base of the bottle, then twist the top piece in a clockwise motion to open. The product should start dispensing after a few pumps.

  • Yes, all VI Derm products are cruelty free. We do not believe in animal testing and choose to partner with suppliers who share our beliefs.

  • The VI Derm SPF 50+ was formulated to prevent breakouts typically experienced with sunscreens. Although it is possible, most people who are acne-prone find great relief in our product.

  • VI Derm products have a shelf-life of 2 years. For those that contain active ingredients you will find a expiration date located on the bottom of the bottle.

  • After proper cleansing, we recommend applying skin care products in the following manner. First serums, then concentrates, moisturizers and finally sunscreen.

  • We only ship to the US.

  • 90. 30 day supply at 3 per day

  • $540 for case of 12

  • $30 on Amazon for 1 month supply

  • $79 with subscription

  • Our scientists developed a new formula that addresses the needs of

    everyone in a single supplement, with ingredients for hair that are backed by scientific data. When reviewing the original

    formula, there were ingredients that support hair health and ingredients that didn’t. We increased the amounts that

    supported hair health and removed those that don’t.

  • See the reformulation comparison document

  • FDA reminds patients, health care professionals and laboratory

    personnel about the potential for biotin interference with certain test results, especially specific tests to aid in heart

    attack diagnoses

    https://www.fda.gov/news-events/fda-brief/fda-brief-fda-reminds-patients-health-care-professionals-and-laboratory-personnel-about-potential

  • https://www.aad.org/dw/dw-insights-and-inquiries/archive/2021/biotin-supplementation-hair-nails

  • 30 men enrolled in the 5 month study

  • Yes, a larger study looking at the efficacy in women will be performed in 2024

  • Your blood is made up of four main components: red blood cells, white blood cells, platelets, and plasma. Platelet Rich Plasma is a platelet concentrated component from your own blood that contains nutrient rich cells and protein growth factors.

  • Platelets are tiny cells that circulate within our body and bind together when they recognize damaged blood vessels. Platelets are made in your bone marrow along with your white and red blood cells.

  • Plasma is the largest component of your blood, making up about 55 percent of its overall content. The primary purpose of plasma is to transport nutrients, hormones, and proteins to the parts of the body that need it.

  • Platelet Rich Plasma is produced when a small amount of blood is drawn and placed into a sterile, disposable container and then, spun to separate the platelets from your blood sample, resulting in a platelet-rich plasma.

  • Platelet Rich Plasma is safe because it comes from your own blood, therefore there is minimal risk for allergic or immune reaction. Platelet Rich Plasma preparation must be conducted by a trained medical professional. Consult your physician for more information.